RARECHEM EM WB 0165
fmoc-D-norleucine
CAS: 112883-41-7
Molecular Formula: C21H23NO4
RARECHEM EM WB 0165 - Names and Identifiers
| Name | fmoc-D-norleucine |
| Synonyms | FMOC-D-NLE-OH Fmoc-D-Nle-OH fmoc-D-norleucine RARECHEM EM WB 0165 N-ALPHA-FMOC-D-NORLEUCINE (R)-2-(Fmoc-amino)caproicacid) (R)-2-(Fmoc-amino)hexanoicacid Fmoc-D-Nle-OH(Fmoc-D-norleucine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-norleucine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-NORLEUCINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-NORLEUCINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-2-AMINOCAPROIC ACID |
| CAS | 112883-41-7 |
| InChI | InChI=1/C21H23NO4/c1-2-3-12-19(20(23)24)22-21(25)26-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,2-3,12-13H2,1H3,(H,22,25)(H,23,24)/t19-/m1/s1 |
RARECHEM EM WB 0165 - Physico-chemical Properties
| Molecular Formula | C21H23NO4 |
| Molar Mass | 353.41 |
| Density | 1.209±0.06 g/cm3(Predicted) |
| Boling Point | 565.6±33.0 °C(Predicted) |
| Flash Point | 295.9°C |
| Vapor Presure | 1.25E-13mmHg at 25°C |
| Appearance | White powder |
| Color | White |
| BRN | 8227505 |
| pKa | 3.91±0.21(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.584 |
RARECHEM EM WB 0165 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2924 29 70 |
| Hazard Class | IRRITANT |
RARECHEM EM WB 0165 - Introduction
Fmoc-D-Norleucine is a chemical reagent commonly used in the study of the synthesis of polypeptides and proteins. The following is a description of the properties, uses, preparation methods and safety information of Fmoc-D-norleucine:
Nature:
Fmoc-D-Norleucine is a white crystalline solid with formula C27H27NO5 and molecular weight 445.50g/mol. Its melting point is about 210-212 degrees Celsius. Fmoc is a protecting group capable of protecting the amino group on the amino group (N-terminus). D-norleucine is an unnatural amino acid that is a stereoisomer of a positive amino acid.
Use:
Fmoc-D-norleucine is mainly used in solid phase synthesis and peptide synthesis. It can be used as a deprotection reagent in solid phase synthesis to remove the amino protecting group Fmoc. In the process of peptide or protein synthesis, Fmoc-D-norleucine can be used as an amino acid monomer, and other amino acid monomers are linked to form a peptide chain.
Preparation Method:
The preparation method of Fmoc-D-norleucine can be accomplished by means of synthetic chemistry. Usually D-leucine is used as the starting material, the amino group is protected first, then Fmoc is protected, and finally Fmoc-D-norleucine is obtained by chemical reaction.
Safety Information:
Fmoc-D-norleucine is a chemical reagent that requires attention to safe operation. It may cause irritation to the eyes, skin and respiratory system, so direct contact should be avoided. Appropriate protective equipment such as lab gloves, glasses and lab coats should be worn during operation. At the end of the operation, the skin should be thoroughly cleaned, and care should be taken not to discharge the reagents directly into the environment, and to handle and dispose of them in accordance with relevant regulations.
Nature:
Fmoc-D-Norleucine is a white crystalline solid with formula C27H27NO5 and molecular weight 445.50g/mol. Its melting point is about 210-212 degrees Celsius. Fmoc is a protecting group capable of protecting the amino group on the amino group (N-terminus). D-norleucine is an unnatural amino acid that is a stereoisomer of a positive amino acid.
Use:
Fmoc-D-norleucine is mainly used in solid phase synthesis and peptide synthesis. It can be used as a deprotection reagent in solid phase synthesis to remove the amino protecting group Fmoc. In the process of peptide or protein synthesis, Fmoc-D-norleucine can be used as an amino acid monomer, and other amino acid monomers are linked to form a peptide chain.
Preparation Method:
The preparation method of Fmoc-D-norleucine can be accomplished by means of synthetic chemistry. Usually D-leucine is used as the starting material, the amino group is protected first, then Fmoc is protected, and finally Fmoc-D-norleucine is obtained by chemical reaction.
Safety Information:
Fmoc-D-norleucine is a chemical reagent that requires attention to safe operation. It may cause irritation to the eyes, skin and respiratory system, so direct contact should be avoided. Appropriate protective equipment such as lab gloves, glasses and lab coats should be worn during operation. At the end of the operation, the skin should be thoroughly cleaned, and care should be taken not to discharge the reagents directly into the environment, and to handle and dispose of them in accordance with relevant regulations.
Last Update：2024-04-10 22:29:15
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